Created by Stan Lee and Steve Ditko, Clea was first introduced in Strange Tales #126, released on August 11th, 1964.
Clea is the niece of the Dread One Dormammu, and she is an immensely powerful wielder of magic from the Dark Dimension. In the comics, she is a friend, ally, and the eventual wife of Dr. Strange.
For much of the time, she was an outside observer to Strange's adventures within the Dark Dimension but eventually became a much more important character within the Marvel continuity.
She would help overthrow her mother, Umar, who, along with Doctor Strange's long-time adversary Baron Mordo, had conquered the Dark Dimension. After seizing control, Clea was made the Sorcerer Supreme of the Dark Dimension, and she would continue to appear on and off in various issues of Dr. Strange comics.
In the latest run of comics, Stephen Strange has been killed following a deal he had been forced to make with Mephisto. Before he dies, he gives her his most trusted tools like the Eye of Agamotto and the Cloak of Levitation, essentially passing down the mantle of Sorcerer Supreme of Earth to her.